Defining the Targets and Function of Antibodies That Protect Against Malaria In Pregnancy

Grant number: 575534 | Funding period: 2009 - 2011

Completed

Abstract

Malaria during pregnancy is a major cause of maternal and infant morbidity and mortality globally. In this project we aim to define the targets of antibodies that protect against malaria in pregnancy and understand the importance of antibody function, determine the extent of antigenic diversity, and identify epitopes of protective antibodies. Results will provide critical knowledge on the development of immunity to malaria in pregnancy that will guide vaccine development.

Related publications (7)

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Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women

DH Opi, MJ Boyle, ARD McLean, L Reiling, JA Chan, DI Stanisic, A Ura, I Mueller, FJI Fowkes, SJ Rogerson, JG Beeson

2021-12-01

Background: The pathogenesis of malaria in pregnancy (MiP) involves accumulation of P. falciparum-infected red blood cells (pRBCs)..

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High Antibodies to VAR2CSA in Response to Malaria Infection Are Associated With Improved Birthweight in a Longitudinal Study of Pregnant Women

ARD McLean, DH Opi, DI Stanisic, JC Cutts, G Feng, A Ura, I Mueller, SJ Rogerson, JG Beeson, FJI Fowkes

2021-06-16

Introduction: Pregnant women have an increased risk of P. falciparum infection, which is associated with low birth weight and pret..

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Does Malaria Affect Placental Development? Evidence from In Vitro Models

AJ Umbers, DI Stanisic, M Ome, R Wangnapi, S Hanieh, HW Unger, LJ Robinson, E Lufele, F Baiwog, PM Siba, CL King, JG Beeson, I Mueller, JD Aplin, JD Glazier, SJ Rogerson

2013-01-31

Background: Malaria in early pregnancy is difficult to study but has recently been associated with fetal growth restriction (FGR)...

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Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity

JA Chan, KB Howell, L Reiling, R Ataide, CL Mackintosh, FJI Fowkes, M Petter, JM Chesson, C Langer, GM Warimwe, MF Duffy, SJ Rogerson, PC Bull, AF Cowman, K Marsh, JG Beeson

2012-09-04

Plasmodium falciparum is the major cause of malaria globally and is transmitted by mosquitoes. During parasitic development, P. fa..

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Antibody to P. falciparum in pregnancy varies with intermittent preventive treatment regime and bed net use

EH Aitken, B Mbewe, M Luntamo, T Kulmala, JG Beeson, P Ashorn, SJ Rogerson

2012-01-27

Background: Antibodies towards placental-binding P. falciparum are thought to protect against pregnancy malaria; however, environm..

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Placental malaria-associated inflammation disturbs the insulin-like growth factor axis of fetal growth regulation

AJ Umbers, P Boeuf, C Clapham, DI Stanisic, F Baiwog, I Mueller, P Siba, CL King, JG Beeson, J Glazier, SJ Rogerson

2011-02-15

Background. The pathogenetic mechanisms of fetal growth restriction associated with placental malaria are largely unknown. We soug..

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Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum

A Ghumra, P Khunrae, R Ataide, A Raza, SJ Rogerson, MK Higgins, J Alexandra Rowe

2011-02-09

Background: Rosetting is a Plasmodium falciparum virulence factor implicated in the pathogenesis of life-threatening malaria. Rose..

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